Identification of novel chronic lymphocytic leukemia subtypes using pathway mutation scores and consensus clustering

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia with variable clinical course underlain by striking genetic heterogeneity. CLL features a handful of putative driver genes and, more interestingly, a large number of non-recurrently mutated genes with elusive clinical implications. The aim of this study was to unravel the prognostic impact of pathway somatic mutation patterns in CLL.