Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: A comparison with imipramine
1991
Abstract The kinetic effects of desmethylimipramine (DMI) on platelet serotonin (5HT) uptake were compared to those of imipramine (IMI) in eight DMI-treated depressed patients and seven IMI-treated depressed patients, and compared to values after patients were off drug for 19 (± 8 SD) and 33 (± 15) days. As expected, IMI was a stronger inhibitor of 5HT uptake than DMI during treatment, with the mean apparent K m in treated patients being elevated nearly threefold over that of the drug-free condition. In DMI-treated patients, the mean K m was elevated nearly twofold over that of the drug-free condition. Although DMI is considered a preferential norepinephrine uptake inhibitor, the results suggest the following: (1) Significant decreases in the apparent platelet 5HT affinity are achieved with DMI; (2) the inhibition kinetics in depressed patients are competitive; (3) there was a significant relationship between K m change and depression outcome with DMI discontinuation; and (40 DMI, as a metabolite, appears to contribute to the %HT uptake inhibition of IMI in vivo.
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