Comparison of Different Methods of Glomerular Filtration Rate in Young Males with Arterial Hypertension

Glomerular filtration rate (GFR) was investigated with different methods in hypertensive young men (18- 27 years) who never had primary disease of the kidney. GFR was evaluated by Rehberg method, Cockcroft-Gault formula, MDRD (Modification of diet in renal disease) formula, MDPvD (methylenedioxypyrovalerone) formula, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula. The normalization of GFR to a standardized body surface area of 1.73 m2. The study showed no significant difference in the mean values of GFR calculated by Rehberg and Cockcroft-Gault formula. The GFR obtained by MDRD, MDPvD, CKD-EPI were respectively lower by 15.5%, 15.6% and 10.0%, compared with the result of the Rehberg method. Similar result was obtained when compared with the values calculated by the Cokcroft-Gault formula: GFR calculated by MDRD, MDPvD, CKD-EPI were respectively lower by 16.0%, 16.1% and 10.4%, respectively. In conclusion, GFR can better be determined in first degree hypertensive patients using Rehberg method or the Cokcroft Gault formula.