CD5-positive diffuse large B cell lymphoma infiltrating the central nervous system presenting Guillain-Barré-like syndrome after chemotherapy.

1) An 83-year-old woman was admitted to our hospital with abdominal pain. Examination revealed mediastinal lymphoadenop- athy, hepatosplenomegaly, and infiltration of abnormal cells into the bone marroww ith hemophagocytosis, and CD5-positive diffuse large B cell lymphoma was diagnosed. Chemotherapy was administered and progressive weakness of the limbs, resembling a Guillain-Barre-like syndrome, subsequently appeared. Cerebrospinal fluid examination indicated lymphoma cell infiltration. Although immune globulin and steroid therapies were not effective, intrathecal injection of methotrexate, predoniso- lone, and cytarabine improved these symptoms. Subsequent to chemotherapy, cell surface antigen changes were observed in the cerebrospinal fluid relative to those in bone marrow. (J Clin Exp Hematopathol 52(3) : 199-204, 2012)