Use of nitrones in the synthesis of potential antihypercholesterolemic and antibacterial mono and tricyclic β-lactams

The hydroxyethyl group at C-3 of a number of monocyclic β-lactams 2a-d is elaborated by a series of reactions to the appropriate side chain meant for acting as cholesterol absorption inhibitor without perturbing the sensitive (3-lactam moiety. In addition, a novel tricyclic β-lactam 2e has also been synthesized using the nitronecycloaddition approach.