Progress in Cardiorespiratory Ischemia-Reperfusion Injury

Sudden cardiac arrest (SCA) is a common cause of death in emergency departments, although SCA treatment has been improved with the improvement of medical and health care, the improvement of cardiopulmonary resuscitation technology, and the use of drugs and other therapeutic measures. However, the survival and discharge rate is still not optimistic. Post-cardiac arrest syndrome (PCAS) is a complex combination of pathophysiological processes, consisting of post-cardiac arrest brain injury, post-cardiac arrest myocardial dysfunction, systemic ischemia-reperfusion response, and persistent precipitating pathology. This part will focus on the latest progress of post-resuscitation myocardial dysfunction, mainly focusing on the mechanism of ischemia-reperfusion injury, to provide basis for clinical treatment.