Glycolate and Oxalate Plasma Levels and Renal Handling in Patients With Type 1 Primary Hyperoxaluria

Detection and differentiation of primary hyperoxaluria type: (PH1) is based on the finding of high urine levels of both oxalate and glycolate. However, these assays may produce misleading results when PH1 is associated with chronic renal failure (CRF). We have recently developed accurate procedures for the determination of oxalate (ion chromatography, IC) and glycolate (HPLC) in both plasma and urine. We have used these techniques to detect and study PH1.