Rosai-Dorfman disease presenting as cervical radiculopathy.

2013 
Rosai-Dorfman disease (RDD) was first reported in 1969 as a are, definitive histiocytic disorder which involves overproduction f a non-Langerhans sinus histiocyte. Most often, the abundance f histiocytes leads to massive lymphadenopathy, leading to the lternative nomenclature of sinus histiocytosis with massive lymhadenopathy (SHML). Histologically it is characterized as sinus istiocytosis with emperipolesis. Emperipolesis, which is the presnce of intact lymphocytes within the cytoplasm of a histiocyte, s opposed to phagocytosis of lymphocytes by a histiocyte, is haracteristic but not pathognomonic of RDD [1]. Patients usually resent in their twenties with cervical lymphadenopathy, fever and eukocytosis. Although lymph nodes are most often involved in DD, extranodal involvement to the soft tissue and central nerous system among others, have been reported [1,2]. Often times ases may mimic metastatic disease as multiple lesions may be een. Cases of CNS involvement in the absence of systemic disase or lymphadenopathy are rare. Most often these spinal masses resent with myelopathy, paresis and plegia [3,4]. Our case report s unique in that the patient presented with cervical sensory adiculopathy and symptoms typical for herniated disc/foraminal tenosis.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    6
    References
    8
    Citations
    NaN
    KQI
    []