Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

Chulwon Kim,Sang Hyun Baek,Jae-Young Um,Bum Sang Shim,Kwang-Seok Ahn

Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

2016

Chulwon Kim
Sang Hyun Baek
Jae-Young Um
Bum Sang Shim
Kwang-Seok Ahn

Background Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

Keywords:

Tyrosine
Transcription factor
STAT5
STAT3 Transcription Factor
Resveratrol
STAT3
Signal transduction
Sorafenib
Cancer research
Medicine
Small interfering RNA
Kinase
Phosphorylation

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