New Approach for Inorganic Anion Analysis by Ion Exchange Chromatography Coupled with Evaporative Light Scattering Detection

Abstract The simultaneous separation of inorganic anions is possible by ion exchange chromatography (IEC) under an isocratic elution mode, using polymer exchanger Metrosep anion dual1 Metrohm (150 × 3 mm ID) followed by evaporative light scattering detection (ELSD). Several mobile phases [formic acid (FA)/ammonia, FA, hydrogen carbonate, trifluoro‐acetic acid (TFA), and heptafluorobutyric acid (HFBA)] were tested for optimization of the separation of inorganic anions. The choice of a mobile phase was proven by compatibility with ELSD volatility requirements.