[Differences in the effects of 6-hydroxydopamine on rat learning with intraventricular and local administration into nuclei of the brain catecholaminergic system].

The role of phospholipid hydrolysis by phospholipase A2 and lipid peroxidation in changes of the properties of beta-adrenoreceptors in rat brain synaptosomes in severe emotional painful stress (EPS) has been evaluated. It has been shown that EPS does not influence lipid and fatty acid content of synaptosomal membranes but significantly increases the amount of lipid peroxidation products. Activation of lipid peroxidation in EPS causes a decrease in specific binding of 3H-dihydroalprenolol. The free radical scavenger, 4-methyl-2,6-di(tret-butyl)phenol completely prevents activation of lipid peroxidation and eliminates the disturbances in ligand-receptor interactions in EPS.