Pharmacokinetic studies of Prethcamide in rats

A simple and sensitive gas chromatographic method for determination of Prethcamide components (I and II) in whole blood and tissues of rats has been developed. The method was used to study disposition of Prethcamide after oral and intravenous administration (60 mg/kg) to rats. Half-lives were found to be low for both constituent of Prethcamide, reaching 7.3 min and 6.5 min for I and II compounds respectively in the blood. They were longest in both cases in the kidney (9.4 min and 8.3 min).