Synthesis,Crystal Structure and Antifungal Activity of 8-Chloro-3-（（4-chlorobenzyl）-thio）[1,2,4]triazolo[4,3-a]pyridine

The title compound 8-chloro-3-((4-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine was prepared from 1-chloro-4-(chloromethyl)benzene and 8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione in the presence of Na OH, and its structure was determined by X-ray diffraction analysis. The crystal is of triclinic system, space group P1 with a = 6.8264(6), b = 7.5890(4), c = 13.0960(7) ?, α = 93.447(4), β = 98.772(6), γ = 92.615(6)o, V = 668.26(8) ?~3, Z = 2, the final R = 0.035 and wR = 0.09 for 2259 observed reflections with I > 2σ(I). The preliminary biological test showed that the title compound has activities against Stemphylium lycopersici(Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory to be 51.19%, 62.02% and 15.56%, respectively.