Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.

Justin T. Ernst,Peggy A. Thompson,Christian Nilewski,Paul A. Sprengeler,Samuel Sperry,Garrick K. Packard,Theodore Michels,Alan Xiang,Chinh V. Tran,Christopher J. Wegerski,Boreth Eam,Nathan P. Young,Sarah Fish,Joan Chen,Haleigh Howard,Jocelyn Staunton,Jolene Molter,Jeff Clarine,Andres Nevarez,Gary G. Chiang,Jim R. Appleman,Kevin R. Webster,Siegfried H. Reich

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.

2020

Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component o...

Keywords:

Eukaryotic Initiation Factor-4A
Protein translation
Biochemistry
Chemistry
RNA Helicase A
eIF4A
Pathogenesis
Cell biology

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