Effects of nizatidine and itopride hydrochloride on esophageal motor function

Background and Aim Nizatidine and itopride hydrochloride inhibit cholinesterase activity and increase acetylcholine in the cholinergic nervous systems. The effect of nizatidine and itopride hydrochloride on esophageal motor function has not been determined, although these drugs are reported to increase gastric motility. Esophageal peristalsis between the upper esophageal sphincter and lower esophageal sphincter (LES) has been shown to be composed of three segments (segments 1–3) using high-resolution manometry. The aim of this study was to clarify the effects of nizatidine and itopride on esophageal motor function using high-resolution manometry.