Gender difference in prognostic impact of in-hospital bleeding after myocardial infarction - data from the SWEDEHEART registry.

Background:Bleeding complications increase mortality in myocardial infarction patients. Potential gender difference in bleeding regarding prevalence and prognostic impact is still controversial.Objectives:Gender comparison regarding incidence and prognostic impact of bleeding in patients hospitalised with myocardial infarction during 2006–2008.Methods:Observational study from the SWEDEHEART register. Outcomes were in-hospital bleedings, in-hospital mortality and one-year mortality in hospital survivors.Results:A total number of 50,399 myocardial infarction patients were included, 36.6% women. In-hospital bleedings were more common in women (1.9% vs. 3.1%, p<0.001) even after multivariable adjustment (odds ratio (OR) 1.17, 95% confidence interval (CI) 1.01–1.37). The increased risk for women was found in ST-elevation myocardial infarction (OR 1.46, 95% CI 1.10–1.94) and in those who underwent percutaneous coronary intervention (OR 1.80, 95% CI 1.45–2.24). In contrast the risk was lower in medically treated...