一种简便高效的Ta 2 O 5 催化溴代芳烃和芳酸的Barbier-Grignard反应制备三级醇

Carried out in THF-toluene at 103° C, the first one-pot Barbier-Grignard reaction to synthesis of tertiary alcohols has been developed and systematically investigated using aromatic acids and unactivated aryl bromides in the presence of 10 mol% of Ta2O5. A wide range of substituted tertiary alcohols were obtained in moderate to good yields of 48-87%. Steric and electronic effects of reactants on the reaction have been discussed. A possible mechanism catalyzed by Ta 2O5 was proposed. Keywords Aryl acid; Barbier-Grignard-type reaction; synthesis; tertiary alcohol