Erlotinib hydrochloride pharmaceutical composition without containing surfactant

The invention discloses an erlotinib hydrochloride pharmaceutical composition without containing a surfactant. The erlotinib hydrochloride pharmaceutical composition comprises the following components in parts by weight: 150-300 parts of erlotinib hydrochloride, 40-250 parts of diluents, 80-190 parts of disintegrants and 5-10 parts of lubricants. The invention also provides a preparation method of the pharmaceutical composition. Use of a special auxiliary material of sodium dodecyl sulfate in the composition is rejected, the problem that in vitro dissolution reaches a dissolution platform under special determination conditions is solved simultaneously, the erlotinib hydrochloride pharmaceutical composition is consistent with a reference preparation, in vivo bioavailability is not affected, and the safety of a product in clinical use is improved.