Endometrium and diabetes

: Endometrium play a fundamental role during the 12 days following conception: its metabolic activity is responsible for the nutrition of the embryo. This nutritive function can be reduced in the presence of maternal diabetes mellitus, with a clinical incidence: unexplained sterility, spontaneous abortion and fetal malformations are more frequent in the presence of poorly controlled maternal diabetes mellitus. These abnormalities are directly correlated to the degree of hyperglycemia and reflect changes in the metabolic activity of the endometrium. Our biochemical study demonstrate that enzymatic activities are responsible, in human endometrium, for glucogene storage in the perovulatory period and energy production during the post ovulatory period; diabetes mellitus is responsible, at least in animal endometriums, for a reduced ability of glucogen storage and a reduced activity of glycolysis enzymes and of glucose 6 phosphate deshydrogenase.