Vstat120 modulates inhibits oncolytic viral therapy induced angiogenesis and innate pro-inflamatory response, augmenting oncolytic viral thereapy of glioblastom multiforme

ii Dedication iv Acknowledgments v Vita vi List of Tables xi List of Figures xiii Chapter 1: Introduction 1 1.1 Glioblastoma multiforme development and prognosis 1 1.2 Angiogenesis and GBMs 3 1.3 Microglia and GMBs 4 1.4 Brain angiogenesis inhibitor-1 6 1.5 Oncolytic Viruses 7 1.6 Hypothesis and overview of Chapters 2-4 10 1.7 Figures and Tables 11 Chapter 2: Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy 12 ix 2.