Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.

Cheryl A. Stoddart,Cheryl Bales,Jennifer C. Bare,George Chkhenkeli,Sofiya A. Galkina,April N. Kinkade,Mary E. Moreno,José Rivera,Rollie Ronquillo,Barbara Sloan,Paul L. Black

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.

2007

Cheryl A. Stoddart
Cheryl Bales
Jennifer C. Bare
George Chkhenkeli
Sofiya A. Galkina
April N. Kinkade
Mary E. Moreno
José Rivera
Rollie Ronquillo
Barbara Sloan
Paul L. Black

Background The SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo. We performed this study to validate the model with representatives of all four classes of licensed antiretrovirals.

Keywords:

Histocompatibility Antigens Class I
In vivo
Severe combined immunodeficiency
Immunology
Virology
Biology
drug licensing
dna viral

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