Analytical Method Development for Tablets of the New Kappa-Opioid Agonist RU-1205

An analytical method for tablets of the new imidazobenzimidazole kappa-opioid agonist RU-1205 was developed. The principal pharmacopoeial parameters of tablet quality were studied. The contents of impurities and RU-1205 in the tablets were assayed quantitatively using HPLC. A method for determining the dose uniformity using UV spectrophotometry was developed. Procedures were proposed for determining the authenticity and dissolution profile of RU-1205 tablets.