Metabolic syndrome and COVID-19;clinical complications and challenges

Hypertension, insulin resistance, hypertriglyceridemia, decreased high-density lipoprotein (HDL) level, and visceral obesity are the main indexes of metabolic syndrome Metabolic syndrome is a cluster of conditions that occur together and increase the risk of cardiovascular diseases and mortality Nowadays, metabolic syndrome has become a global epidemic and approximately 20-25 percent of the world's adult population possess the potential risk factors for developing this disorder Several studies have shown that patients with various metabolic disorders such as obesity, diabetes, hypertension, and cardiovascular diseases are more susceptible to coronavirus disease 2019 (COVID-19) Furthermore, patients with underlying conditions associated with metabolic syndrome are at higher risk for complications and mortality of COVID-19 Therefore, understanding the mechanisms underlying the crosstalk between COVID-19 and metabolic syndrome are necessary for better management of the affected patients The aim of the current review was to review any correlation between metabolic syndrome and the COVID-19 infection in terms of the severity in clinical complications and mortality