Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

Margit Hagel,Deqiang Niu,Thia St. Martin,Michael P. Sheets,Lixin Qiao,Hugues Bernard,Russell Karp,Zhendong Zhu,Matthew T. Labenski,Prasoon Chaturvedi,Mariana Nacht,William F. Westlin,Russell C. Petter,Juswinder Singh

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

2011

Margit Hagel
Deqiang Niu
Thia St. Martin
Michael P. Sheets
Lixin Qiao
Hugues Bernard
Russell Karp
Zhendong Zhu
Matthew T. Labenski
Prasoon Chaturvedi
Mariana Nacht
William F. Westlin
Russell C. Petter
Juswinder Singh

A potent hepatitis C virus protease protein inhibitor forms an irreversible covalent bond to a virally conserved noncatalytic cysteine in the protease substrate-binding pocket identified in a bioinformatic analysis.

Keywords:

Molecular biology
Protease
Hepatitis C virus
Biochemistry
Cysteine
Biology
Covalent bond
proteinase inhibitor

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