The Vascular Concept

The phenotypic expressions of rosacea have been suggested to be caused by divergent pathogenetic factors. Although its precise etiology remains unknown, various factors have been suspected of contributing to this condition (Table 81.1). Recently, familial cases of rosacea have been reported, and a genetic predisposition to the disease has been suggested. In addition, ultraviolet (UV) light-induced skin changes, such as solar elastosis and vessel dilatation as well as immunosuppression, have been accused to contribute in the development of rosacea [1].