Sıçan Karaciğeri Üzerine Tiyopental Sodyum ve Propofolün Etkileri

Aim: This study was conducted to investigate the histopathological and biochemical effects of propofol and sodium thiopental, which are intravenous anaesthetics used in surgical operations on rat liver. Material–Method: There were three study groups each consisting of nine animals: Control (n=9), propofol (n=9) and sodium thiopental (n=9) group. Propofol (20 mg / kg / day, i.p) and sodium thiopental (60 mg / kg / day, i.p) were administered with one day interval for 20 days. Findings: At the end of the study, liver tissues were taken for histological examination and for biochemical analysis. There was a significantly increase in MDA level in propofol exposed group, when compared with the controls and this was statistically significant. We found significant damage in histological sections in paralel to biochemical findings. These histological changes hepatocyte degeneration, vascular congestion and mononuclear cell infiltration in different sites and bile duct proliferation observed in propofol and this was statistically significant. MDA levels were significantly increased in sodium thiopental given group. Also, SOD and CAT activities were prominent in this group. Also, more histological changes like hepatocyte degeneration, vascular congestion and mononuclear cell infiltration in different sites were observed in sodium thiopental and this was statistically significant. Results: As a result, we can say that these intravenous anaesthetic agents may cause dose dependent damage in liver tissue. For this reason, we think that one must take care of the administration duration and dose levels of the anaesthetics during surgical operations. Key Words: Propofol, Thiopental sodium, liver, oxidative damage.