Informational liposomes: Complexes derived from cholesteryl-conjugated oligonucleotides and liposomes

Abstract Oligonucleotides with cholesteryl groups tethered near one or both termini bind efficiently to liposomes. Liposomes tagged with such oligonucleotides are recognized by complementary oligonucleotides free in solution or bound to a membrane, as shown by experiments in which the liposomes are precipitated or are immobilized on a membrane as a consequence of hybridization.