Low Density Lipoprotein Particle Size in Adults Receiving Conventional Hormone Therapy* Hypopituitary Replacement

Adults receiving conventional replacement therapy for hypopituitarism are known to have increased cardiovascular mortality. The aim of this study was to assess the lipid profiles of 30 hypopituitary adults compared with 2 case control groups, 1 matched for age, sex, and body mass index (BMI) and the second matched for age and sex only with a BMI representative of the general population. Fasting lipids, lipoproteins, and apoproteins (APO) were determined by routine methods. Low density lipoprotein (LDL) particle size was determined by nondenaturing gradient gel electrophoresis. LDL size was significantly smaller in the hypopituitary group (25.9 ? 0.1 nm) than in the BMI-matched (26.2 -C 0.1 nm; P < 0.05) and standard control (26.3 ? 0.1 nm; P < 0.01) groups. High density lipoprotein cholesterol levels in the hypopituitary group were significantly lower than those in the BMI-matched control group (1.13 2 0.06 us. 1.34 2 0.06 mmol/L; P < 0.05) and the standard control group (1.38 i- 0.06 mmol/L; P < 0.005). Apo Al levels were also lower compared with those in the BMI-matched (122 + 6 us. 137 i- 4 me/dL: P < 0.05) and the standard (143 2 4 mg/dL; P < 0.005) control o P = 0.061. These differences were more marked in the female subjects studied. No significant differences were noted in total cholesterol, LDL cholesterol, or Apo B levels. We conclude that hypopituitary patients receiving conventional replacement therapy have an atherogenic lipid profile characterized by small dense LDL, decreased high density lipoprotein cholesterol, and increased triglyceride levels, which may contribute to the excess cardiovascular mortality in this group.