Clinicopathological significance of false-positive lymph node status on 18F-FDG PET in lung cancer

Abstract Introduction 2-[18F] Fluoro-D-deoxyglucose positron emission tomography (FDG-PET) is a relevant diagnostic procedure for staging lung cancer. However, accurate evaluation of lymph node metastases by PET is controversial, because of false-positive FDG uptake. Methods A total of 245 patients with lung cancer were retrospectively analyzed. Maximum standardized uptake (SUVmax) values of the primary tumor and lymph nodes were compared with pathological lymph node metastases to correlate PET findings with clinicopathological variables and patient outcomes. Results The SUVmax values of metastatic lymph nodes were significantly higher than those of lymph nodes without metastases (p=0.0036). When SUVmax ≥4 was defined as PET-positive for metastasis, sensitivity, specificity, and accuracy were 48.1%, 79.8%, and 73.1%, respectively. Multivariate logistic regression analysis showed that age >75 years, bilateral hilar FDG uptake, and no lymph node swelling were significant factors related to false-positive lymph node metastases. Smoking status, FDG uptake in the primary tumor, and concurrent lung diseases were not significant factors. Conclusion Metastatic lymph nodes show higher FDG uptake than false-positive lymph nodes, and older patient age, bilateral hilar FDG uptake, and no swollen nodes are associated with no metastases. Patients with lymph node metastases have worse survival than those with false-positive FDG-PET findings. However, abnormal FDG uptake in the lymph node is an important prognostic factor.