[Comparative studies of the antiarrhythmic activity of prolonged action quaternary ammonium derivatives of trimecaine (G-104) and lidocaine (QX-572)]

The antiarrhythmic activity of quaternary ammonium derivatives of trimecaine (G-104) and lidocaine (QX-572) was studied on models of arrhythmias induced in dogs by coronary artery occlusion and strophanthin intoxication and in rats by intravenous administration of aconitine. It was found that the antiarrhythmic activity and duration of action of G-104 exceed those of QX-572. The data obtained by the method of electromagnetic flowmetry showed that G-104 in doses of 0.3 and 1 mg/kg produces insignificant changes of hemodynamic parameters. By its action on transmembrane ion currents, G-104 is close to quinidine-like agents.