Embolia cutis medicamentosa (Nicolau-Syndrom) nach intraartikulärer Injektion

Embolia cutis medicamentosa (Nicolau Syndrom) is very rare complication of intramuscular injections which presents with extensive necrosis of the injected skin area. Intra-arterial and/or para-arterial injections after prior perforation of certain vessels are discussed as possible pathogenetic mechanisms.We describe the occurrence of embolia cutis medicamentosa after intra-articular injections into the knee.