Research progress of N6-methyladenosine in reproduction area

Among various RNA methylations, N6-methyladenosine (m6A) is the most commom one.m6A is ubiquitous in diverse biological-process. Because of the development of new technologies, structures of m6A methyltransferases, demethylases and binding proteins were discovered in succession. Close attention was paid on m6A for its important biological functions to mRNA and non-coding RNA. The health of reproduction is growing concern in the medical field. In this paper, we reviewed the latest research of m6A’s significant influences on gametogenesis; zygote development, gynecological endocrine disease and reproductive system tumor. Key words: N6-methyladenosine; Gametogenesis; Zygote development; Gynecological endocrine disease; Reproductive system tumor.