[48-OR]: Association of paternal allelic polymorphisms of HLA-C with the development of preeclampsia

Objectives The development of preeclampsia is considered to be related to maternal immune and genetic factors. HLA-C is one of the major histocompatibility antigens that plays an important role in regulating maternal fetal interface. However, epidemiological studies show that paternal risk factors can play a role in the development of preeclampsia. The aim of this study is to explore the relationship between paternal and fetal HLA-C allelic polymorphisms and preeclampsia in Chinese Han population. Methods 34 spouses and fetuses of women with preeclampsia and 37 spouses and fetuses of healthy pregnant women were included in the case-control study. All pregnant women were at the third trimester of gestation. The HLA-C genes from blood genomic DNA were genotyped by polymerase chain reaction–sequencing-based typing (PCR-SBT) genotyping method. The associations of HLA-C alleles with the disease were expressed as P and odds ratios (ORs). Results No differences were observed in the spouses’ age, body mass index, contraception method or previous history of hypertension and cardiovascular disease. Gestational age was shorter (36.39 ± 3.15 vs. 39.31 ± 1.14, p p ∗ 08:01:01G was significantly higher in the spouses of preeclamptic women, compared with that in the spouses of normotensive women (14.7 vs. 2.7%, P  = 0.010, OR = 6.207, 95%CI (1.308, 29.451)). There was no statistical difference in the frequency of fetal HLA-C alleles ( p  > 0.05). Conclusions Pregnant women with spouses carrying HLA-C ∗ 08:01:01G have a greater risk for the developing of preeclampsia in Chinese Han population. Disclosures H. Yu: None. N. Pan: None. Y. Shen: None. S. Jin: None. J. Zhai: None. D. Qiao: None. L. Chen: None. W. Xu: None. F. Miao: None. Y. He: None. M. Ren: None. J. Zhang: None.