ZNF232: structure and expression analysis of a novel human C2H2 zinc finger gene, member of the SCAN/LeR domain subfamily

Abstract We have identified a novel zinc finger gene, ZNF232 , mapped to human chromosome 17p12. The coding region of the gene is organized in three exons corresponding to a 417 amino acid long polypeptide containing a SCAN/LeR domain and five C 2 H 2 -type zinc fingers. ZNF232 is possibly a nuclear protein, as suggested by expression analysis of GFP/ZNF232 chimeric constructs. ZNF232 transcripts were detected in a wide collection of adult human tissues. The gene is possibly subjected to tissue-specific post-transcriptional regulation by means of alternative splicing.