Maternal Gut Microbiota Displays Minor Changes in Overweight and Obese Women with GDM

Abstract Background and Aims Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks’ gestation. Methods and Results This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort. Overweight and obese women with no impaired glucose tolerance or impaired fasted glucose were enrolled prior to gestational age Conclusions Overweight and obese women with GDM demonstrate minor variation in the gut microbiota at 16 and 28-weeks’ gestation compared with matched euglycaemic women. This study expands on previous literature concluding the microbiota does not likely have a disease-specific characterisation in GDM.