Circulating regulatory T-cells as a pregnancy marker of immunological testing for predicting adverse pregnancy outcomes: A preliminary study

Results: In the group c was higher the percentage of ACLAG, IL-6 (p=0.002), 18 (p=0.016) and 23 (p=0.002) and ACLA-G (p<0.001). In other pathologies was higher only percentage of ACLA-M (p<0.001). ROC analysis shows, that ACLA-G were positive in 25% of preeclampsia and in no other pathologies (sensitivity 25%, specificity 98.6%, PPV 80%, NPV 85.5%). ACLA-M were positive in no preeclampsia but it were positive in 14.9% of other pathologies (sensitivity 14.9%, specificity 100%, PPV 100%, NPV 28.6%). IL-15 was positive only in the patients who developed severe preeclampsia. IL-16was elevated only in the group a. Other parameters did not differ significantly. Conclusions: This study has shown that, in general, the evaluation of selected immunological markers can help to contribute to the prediagnostics of patients with preeclampsia in the third trimester. The occurrence of ACLA-G in the first trimestermay indicate the risk of preeclampsia in the further course of pregnancy, while first-trimester ACLA-M are connected rather with the other pathologies. Acknowledgement: This research was supported by PRVOUKP25/LF1/2 and MZCR-RVO-VFN 64165.