Enteric Coating Materials Choline fenofibrate capsules release pellets

The present invention relates to an enteric film choline fenofibrate controlled release pellet capsules, the pellets which release coating film EurdragitRS 30D employed as the film forming material pellet core contains high expansion low substituted hydroxypropyl fibers element, and a pharmaceutically acceptable sustained-release pellets commonly used excipients such as, preferably microcrystalline cellulose, wherein the pellet core low-substituted hydroxypropyl cellulose pellet core weight percentage of 10 to 40%. Sustained release film coating comprising Eurdragit RS 30D, a plasticizer triethyl citrate and talc antisticking agent, preferably in a ratio of triethyl citrate Eurdragit RS 30D:: talc = 30:3:4, by coating preferably from 20 to 38 weight%. Because it contains water having a high expansion Low-substituted hydroxypropylcellulose pellet core, significantly swell after absorbing water, resulting in release coating film is stretch, reducing the thickness, pore size becomes larger micropores permeable, the permeability better, decreased membrane permeability compensated by aging, such that substantially constant release rate in the latter part, the end of the remaining small, can always keep a stable release properties within the validity period.