Pd/C-mediated coupling of aryl halides with terminal alkynes in water
2005
Abstract 2-Aminoethanol facilitated the alkynylation of aryl halides (Sonogashira reaction) under palladium/charcoal–copper catalysis in water affording a mild and practical method for the synthesis of arylalkynes. A variety of terminal alkynes were coupled with aryl iodides and bromides possessing no hydrophilic functional groups to give the coupled products in good to excellent yields.
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