[Long-term outcome and analysis of prognostic factors in 114 cases of postoperative stage III gastric cancer].

Objective To analyze the results of long-term follow up of patients with postoperative stage Ⅲ gastric cancer and the prognostic factors.Methods We retrospectively analyzed the clinicopathological data of 114 patients with stage Ⅲ gastric cancer treated in our hospital from April 1998 to January 2006.Kaplan-Meier univariate analysis and Cox regression analysis were performed to evaluate the candidate prognostic factors,such as gender,age,pathological stage,histological differentiation,lymphovascular tumor thrombus,tumor residual and postoperative chemotherapy.Results In the 114 cases,the 5-year overall survival rate was 28.6％ and 10-year survival rate was 22.6％.The 5-year survival rates of stage ⅢA,Ⅲ B and Ⅲ C patients were 38.3％,33.8％ and 19.5％,respectively,and 10-year survival rates were 33.5％,29.6％ and 11.1％,respectively.Univariate analysis showed that pathological stage,tumor residual and postoperative chemotherapy were significantly correlated with prognosis (P ＜ 0.05).Multivariate analysis showed that pathological stage,tumor residual and postoperative chemotherapy were independent prognostic factors of stage Ⅲ gastric cancer patients (P ＜ 0.05 for all).Conclusions The long-term survival of stage Ⅲ gastric cancer patients remains poor.Pathological stage,tumor residual and postoperative chemotherapy are the most significant factors influencing prognosis of stage Ⅲ gastric cancer after radical resection.Postoperative chemotherapy can improve their survival. Key words: Stomach neoplasms ;  Prognosis;  Factor analysis, statistical