Ossifying fibromyxoid tumor of buccal mucosa: Report of a rare case and review of the literature

Abstract An ossifying fibromyxoid tumor (OFMT) is a tumor with borderline malignant potential that usually arises in the subcutaneous tissue of the extremities, trunk, head, and neck and is rarely found in the oral cavity. In 1989, Enzinger et al reported this tumor, in which Schwannian and cartilage cells play important developmental roles; however, this remains to be clarified. We report a rare case of OFMT that arose in the buccal mucosa. A 63-year-old Japanese n noticed an indurated mass in his right buccal mucosa, which gradually increased in size. Radiography with contrast showed a large (2 × 1.5 cm) mixed lesion with connective and osteoid tissues. The lesion was completely resected, and the excised specimen showed features of an atypical OFMT. At 1-year follow-up, the patient was disease-free. This report presents this rare case of OFMT of the buccal mucosa and discusses the importance of correct diagnosis and complete surgical removal in the treatment of this lesion.