1-(N-chloroacetylamino)-alkylphosphonic acids : synthetic precursors of phosphonopeptides

General procedures of N-chloroacetylation of the representative 1-aminoalkylphosphonic acids (GlyP, AlaP, ValP, PglyP and PheP) are described. These 1-(N-chloroacetylamino)-alkylphosphonic acids were converted into the corresponding glycylphosphonodipeptides (Gly-AAP) and/or related N-alkylglycylphosphonodipeptides (MenGly-AAP) in the course of ammonolysis/aminolysis. Physico-chemical properties of synthesized 1-(N-chloroacetylamino)-alkylphosphonic acids and phosphonodipeptides are characterized.