Comparison of Three Days’ Therapy with Cefcanel or Amoxicillin for the Treatment of Acute Uncomplicated Urinary Tract Infection

The clinical and bacteriologic efficacy of 3 days of cefcanel daloxate therapy, compared with 3 days of amoxicillin for the treatment of acute uncomplicated urinary tract infection was compared in a prospective randomized double-blind multicentre study. 400 subjects were randomized to receive cefcanel daloxate and 199 to receive amoxicillin. 166 (77%) of 215 evaluable cefcanel daloxate subjects and 72 (77%) of 94 evaluale amoxicillin subjects evidenced bacteriologic elimination at short-term follow-up, while in 149 (69%) and 67 (71%), respectively, clinical symptoms disappeared. At long-term follow-up, 150 (70%) cefcanel daloxate and 65 (69%) amoxicillin subjects evidenced bacteriological elimination, while in 150 (70%) and 61 (65%), clinical symptoms disappeared. There were no significant differences in outcome between the 2 therapeutic regimens. Adverse events were similar in the 2 groups. In additional analyses, antimicrobial efficacy diminished significantly with increasing age, preth-erapy in vitro s...