Novel 10-23 deoxyribozyme analogue and application thereof

The invention relates to a novel 10-23 deoxyribozyme analogue and application thereof. Specifically, the invention relates to a 10-23 deoxyribozyme analogue shown in the following formula, wherein a catalytic structure domain part of 10-23 deoxyribozyme is modified, and each symbol is described in the description. The invention also relates to a preparation method of the 10-23 deoxyribozyme analogue, medicine boxes, kits or combinations of the 10-23 deoxyribozyme analogue and applications thereof. In the 10-23 deoxyribozyme analogue, in consideration of different conservative properties of all nucleotide units in the catalytic structure domain of the 10-23 deoxyribozym and the contribution of the functional groups of the basic group to the catalytic reaction, analogues of purine nucleoside and pyrimidine nucleoside are used for replacing positions of purine nucleoside and the pyrimidine nucleoside in the catalytic structure domain so as to obtain the novel deoxyribozyme analogue, the catalytic efficiency of which is higher than that of the traditional 10-23 deoxyribozyme analogue.