Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine

Abstract Background Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP- fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP- fve is still unknown. Objective We hypothesized that orally administrated FIP- fve should be able to reduce airway remodeling in chronic allergic models. Methods The chronic asthma animal model was established with 6–8 weeks female Balb/c mice. After intranasal challenges with OVA, the airway inflammation and AHR were determined by a BUXCO system. BALF was analyzed with Liu's stain and ELISA assay. Lung histopathologic changes and Collagen deposition were assayed with H&E, Masson's trichrome and IHC stain. Results FIP- fve significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines and increased Th1 cytokines in BALF and serum compared with the OVA sensitized mice. FIP- fve had a better effect than corticosteroid could reduce infiltrating cells in lung especially neutrophils and eosinophils. We also found that the oral FIP- fve group suppressed IL-17 and enhanced IL-22 in the serum and BALF. In addition, oral FIP- fve decreased MMP9 expression, collagen expression and airway remodeling in lung tissues. Conclusion FIP- fve had anti-inflammatory effects on OVA-induced airway inflammation and an effect to inhibited Th17 cells to reduced airway remodeling and collagen expression. Moreover, FIP- fve might be a potential alternative therapy for allergic airway diseases.