Abstract P025: Trimethylamine N-oxide Not Associated with Coronary Artery Calcium in Healthy, Young Adults with Normal Kidney Function: Coronary Artery Risk Development in Young Adults Study, 2000-2011

Objective: Trimethylamine N-oxide (TMAO), a gut microbiota-dependent nutrient metabolite, has been implicated in the development of cardiovascular disease (CVD). TMAO is excreted in the urine and high levels may reflect poor kidney function, an independent risk factor for CVD. We tested the association between TMAO and coronary artery calcium (CAC) in a young, healthy sample of US adults with normal kidney function. Methods: Study participants were from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a multicenter cohort of black and white Americans established in 1985/86 (baseline n=5,115; ages 18-30). CAC was measured at follow-up years 15, 20, and 25 with computed tomography (CT). Among a subsample of participants with no detectable CAC at year 15 who had complete CAC data (years 15, 20, 25) and covariate data (year 15) (n=746), we measured TMAO (uM) in year 15 stored plasma (-70 C) and defined incident CAC as having total Agatston units ≥ 0 across all arteries at year 20 or 25. TM...