Chronicidiopathicurticaria andGraves'disease

Chronic urticaria is a common condition charac- terized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions lasting for more than 6 weeks. In about 75% of cases, the underlying causes remain unknown, and the term chronic idiopathic urticaria (CIU) is used to em- phasize that wheals develop independently of identified ex- ternal stimuli. Although CIU affects about 1.0% of the gener- al population, its etiopathogenesis is not yet well understood. It is now widely accepted that in many cases CIU should be re- garded as an autoimmune disorder caused by circulating and functionally active IgG autoantibodies specific for the IgE re- ceptor (FceRI) present on mast cells and basophils or for IgE it- self. The well-known association of CIU with other autoimmune processes/diseases represents further indirect evidence of its autoimmune origin. Autoimmune thyroid diseases, especially autoimmune thyroiditis, represent the most frequently inves- tigated diseases in association with CIU. Here we review this topic with particular regard to the association between Graves' disease and CIU. The possible pathogenetic mechanisms and the clinical implications of such an association are discussed. (J. Endocrinol. Invest. 36: 531-536, 2013) ©2013, Editrice Kurtis