Factors related to FDG uptake observed in the red bone marrow

1685 Objectives The purpose of this study was to analyze the factors related to mild to moderate FDG uptake occasionally observed in the bone marrow in patients without any pathological lesions. Methods We reviewed a total of 207 PET images of patients who had had no systemic chemotherapy, administration of G-CSF or bone lesions. They were classified into three groups according to the degree of uptake in the bone marrow: Group A, no or faint uptake (n=143); Group B, mild uptake comparable with the liver (n=50); and Group C, uptake more than that in the liver (n=14). We evaluated the relationship between the uptake and factors, including gender, age, plasma glucose level, and hematological parameters. Results There were significant differences of the values in age, hemoglobin level, white blood cell count, and platelet count among the groups by the Kruskal Wallis test. The logistic regression analysis showed that independent factors including younger age and higher level of white blood cell were associated with higher uptake. Conclusions Our preliminary data indicate that white blood cell count and age seem to be associated in some way with FDG uptake in the bone marrow.