Running title: Role of NFAT5 in placental hypoxia and ischemia

During gestation, low oxygen environment is a major determinant of early placentation process, while persistent placental hypoxia leads to pregnancy-related complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR). PE affects 5-8% of all pregnancies worldwide and is a cause of maternal and fetal morbidity and mortality. During placental