Prognostic Evaluation of Patients With Multicentric Papillary Thyroid Microcarcinoma

2011 
Background/Purpose Patients with papillary thyroid microcarcinoma (PTMC) often have an excellent prognosis. We hypothesize that patients with multicentric PTMC are associated with good clinical outcome, although multicentricity in papillary thyroid carcinoma may be associated with poor prognosis. Methods Retrospective analysis of multicentric PTMC cases in one medical center enrolled from 1987 to 2008 was conducted. At the end of follow-up, patients were classified as “recurrence-free” or “recurrence or persistent disease”. The tumor-node-metastasis (TNM) staging system was used, and (T1, N0, M0) was regarded as “early clinical stage”, whereas (T3–4, any N, any M) or (any T, N1, or M1) was regarded as “advanced clinical stage”. Results There were 61 patients with a median age of 45 years. After a median follow-up period of 7.3 years (range: 2.1-22.1 years), the overall cause-specific survival rate was 98.36%. The patients with tumor diameters Conclusion Our results demonstrate excellent prognosis in multicentric PTMC patients. No patients with tumor diameter
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