IDDF2019-ABS-0154 Upper gastrointestinal tract involvement in crohn’s disease in china: frequency, endoscopic features, related factors, and prognosis

Background The clinical studies in the field of UGI-CD are scarce in China. A retrospective cohort study was performed to analyze the clinical characteristics of UGI-CD. Methods Patients at Shanghai Ruijin Hospital from 2014 to 2016 were consecutively enrolled. They were divided into UGI+ group and UGI- group based on endoscopy and pathology results. Features of UGI-CD were analyzed and the prognosis was followed-up. Results 76 subjects were enrolled in this study. (1) 46 cases (60.5%) had 68 positive endoscopic manifestations. Endoscopic features were diverse and the bamboo joint-like appearance of the gastric fundus had the highest incidence, followed by duodenal ulcers and bamboo joint-like appearance of the duodenal bulb (table 1 and figure 1). According to the UGI-SESCD, patients with a score of 5 and above accounted for only 23.9%. (2) Male sex and presence of ileocolon lesions were independent risk factors for UGI-CD (p (3) No significant difference between the UGI+ group and the UGI- group in the 3-year no surgery and the 3-year no complication rates(p> 0.05). Further subgroup analysis showed that the 3-year event-free survival rate in the UGI+DB+ group (68.0%) was significantly lower than that in the UGI- (88.9%) and UGI+DB- (87.9%)groups (p = 0.015). Conclusions Upper gastrointestinal tract involvement in newly diagnosed CD patients is not rare. UGI+ patients with duodenal bulb involvement had significantly higher rates of surgery or complications. Therefore, active treatment should be promptly provided to this subgroup of patients to improve their prognosis.